Usha P Andley Selected Research

Crystallins (Crystallin)

1/2021	Analysis of amyloid-like secondary structure in the Cryab-R120G knock-in mouse model of hereditary cataracts by two-dimensional infrared spectroscopy.
7/2020	Changes in relative histone abundance and heterochromatin in αA-crystallin and αB-crystallin knock-in mutant mouse lenses.
7/2020	Creatine kinase/α-crystallin interaction functions in cataract development.
1/2020	Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts.
1/2019	Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts.
9/2018	In vitro interactions of histones and α-crystallin.
1/2018	Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.
1/2016	Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts.
11/2015	Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.
1/2014	In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin.

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Usha P Andley Research Topics

Disease

28	Cataract (Cataracts) 01/2022 - 03/2002
6	Genomic Instability 09/2009 - 08/2003
2	Muscular Diseases (Myopathy) 01/2021 - 03/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 09/2007
2	Blindness (Hysterical Blindness) 11/2011 - 06/2010
2	Necrosis 07/2010 - 11/2004
2	Starvation 12/2004 - 10/2004
1	Desmin-Related Myofibrillar Myopathy 03/2011
1	Infections 07/2010
1	Eye Infections 07/2010
1	Phototoxic Dermatitis (Phototoxicity) 07/2010
1	Aneuploidy (Aneuploid) 09/2005
1	Neoplasms (Cancer) 07/2004
1	Autosomal Dominant Cataract 10/2003

Drug/Important Bio-Agent (IBA)

32	Crystallins (Crystallin)IBA 01/2021 - 03/2002
18	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2003
6	alpha-Crystallins (alpha-Crystallin)IBA 01/2020 - 10/2003
4	Arginine (L-Arginine)FDA Link 01/2021 - 03/2002
3	TubulinIBA 05/2006 - 09/2003
2	OxysterolsIBA 01/2022 - 01/2019
2	VP1-001IBA 01/2022 - 01/2019
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2021 - 10/2013
2	Protein AggregatesIBA 01/2021 - 10/2013
2	Histones (Histone)IBA 07/2020 - 01/2014
2	Small Heat-Shock ProteinsIBA 04/2013 - 09/2005
2	Retinaldehyde (Retinal)IBA 06/2010 - 08/2003
2	Cysteine (L-Cysteine)FDA Link 02/2008 - 03/2002
2	Molecular Chaperones (Chaperone, Molecular)IBA 05/2006 - 09/2003
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2005 - 09/2003
2	Bromodeoxyuridine (BrdU)IBA 12/2004 - 10/2004
1	Amyloid (Amyloid Fibrils)IBA 01/2021
1	Creatine Kinase (Creatine Phosphokinase)IBA 07/2020
1	Adenosine Triphosphate (ATP)IBA 07/2020
1	Amino Acids FDA Link 01/2020
1	Therapeutic UsesIBA 01/2019
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Hemoglobins (Hemoglobin)IBA 01/2014
1	Phosphoglycerate Mutase (Phosphoglyceromutase)IBA 01/2014
1	Cytoskeletal ProteinsIBA 04/2013
1	N'-formylkynurenineIBA 11/2011
1	KynurenineIBA 11/2011
1	Intermediate Filament ProteinsIBA 03/2011
1	Biological ProductsIBA 03/2011
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2010
1	Ciprofloxacin (Cipro)FDA LinkGeneric 07/2010
1	Anti-Bacterial Agents (Antibiotics)IBA 07/2010
1	FluoroquinolonesIBA 07/2010
1	Neomycin FDA LinkGeneric 07/2009
1	Mutant Proteins (Protein, Mutant)IBA 09/2008
1	PeroxidesIBA 09/2005
1	hypericinIBA 11/2004
1	DNA (Deoxyribonucleic Acid)IBA 10/2004
1	Factor VII (Proconvertin)IBA 07/2004
1	CalciumIBA 07/2004
1	glucocorticoid receptor alphaIBA 07/2004
1	AntibodiesIBA 09/2003

Therapy/Procedure

15	Lenses 01/2022 - 09/2003
1	Slit Lamp 01/2022
1	Topical Administration 01/2019
1	Therapeutics 10/2006